Target deep wrinkles NeoCutis Bio Serum Bio-Restorative Serum Intensive Spot Treatment. Oftentimes, deep-set wrinkles around the eyes, mouth, and forehead are caused by repetitive facial expressions, and many believe them to be permanent – they’re not. This intensive spot treatment will specifically target these stubborn lines with a concentrated formula that has ingredients such as PSP, or cytokines, interleukins, and growth factors, and hyaluronic acid that will help achieve results quickly. This product is unique in that it contains 100% more PSP than any other product in the NeoCutis line. Because of its potent formula filled with PSP, this serum will instantly hydrate, plump, smooth, and firm mature skin, leaving visible improvements to spots such as crow’s feet, nasal labial folds, lip contours, forehead lines, and regular wrinkles and fine lines. The portable pen applicator design will help deliver a precise dosage to the problem areas. This non-comedogenic, color additive-free, and fragrance-free product is perfect for all skin types.